京东影业影视传媒

, 17, of Sapporo, Japan, won first place and received the George D. Yancopoulos Innovator Award of $100,000 for his work to predict how materials can fold in complex ways. He created a simulation program to understand complex folding, like in origami. Current methods for predicting folding can either only trace one path at a time or fail to test all the possibilities. Hikaru’s simulation software uses a statistical method called Markov Chain Monte Carlo. This method samples many possible scenarios and uses those patterns to estimate the most probable answers. It allows the simulation to examine all possibilities at once in a single run. Hikaru’s software predicted known solutions, such as the folding of a ladybug wing. This program could help design devices that need to be packed into small spaces and unfolded later, such as solar sails for satellites, medical devices or emergency pop-up shelters.

, 18, of Bellevue, Washington, received the Regeneron Young Scientist Award of $75,000 for a sponge that removes salmon-killing pollutants from water. When adult coho salmon spawn, they return to the urban streams of Washington鈥檚 Puget Sound region. In some streams, up to 80% of these fish die before spawning. These streams are polluted with a chemical from tires called 6PPD-quinone. Previous work found that 6PPD-quinone was a primary cause of these salmon deaths. To remove the pollutant from water, Lakshmi created sponge-like filters from jute plant waste. In laboratory tests of water with tire particles, she showed the filters removed up to 80% of the pollutant. It can also remove other heavy metals and particles. It also naturally breaks down in the environment. Compared with current alternatives, Lakshmi鈥檚 solution required 85% less energy to produce and reduced costs by about 98%. Her work may lead to a scalable way to protect aquatic ecosystems and drinking water from tire-related contaminants.

, 17, of Sofia, Bulgaria, received the Regeneron Young Scientist Award of $75,000 for describing a new theorem in mathematics. Mathematicians have found that equations that follow f(x) = a can be solved with basic math functions, except in a few specific cases. Nikola analyzed those isolated cases of unsolvability to find a common thread. He combined several advanced mathematical concepts. He combined ideas from topology, symmetry and Galois theory. He used these approaches to analyze when equations become impossible to solve exactly. By doing this, he described the conditions under which the equation f(x) = a cannot be solved using basic math functions. His work may impact equations used in physics and in describing how objects move through space.

, 15, of Ontario, Canada, received the聽Gordon E. Moore Award for Positive Outcomes for Future Generations of $50,000 for making an AI-powered imaging robot to find and measure tiny pieces of plastic in water. Microplastics threaten animals and aquatic ecosystems worldwide. Current ways to measure microplastics are costly and hard to implement. To create a faster and more practical solution, Evan designed and built an underwater 3D holographic camera. The camera is mounted on a self-propelled robot that swims through the water like a sea turtle. He also trained AI models to find pieces of plastic smaller than a red blood cell in the underwater images. His models were 94% accurate at telling microplastics apart from other particles. He tested it in 10 bodies of water, scanning more than 80,000 3D images for plastic particles and microorganisms. His work could make it easier and faster to monitor water sources for microplastics.

, 15, of Bellevue, Washington, received the F. Thomson Leighton and Bonnie Berger Family Prize for STEM Excellence of $50,000 for her music therapy device. Although music therapy is a recognized approach for supporting mental health, access is limited. Cost, provider shortages and lack of insurance coverage make music therapy inaccessible. To combat this, Anusha created a portable music therapy device. Her platform delivers tailored, adaptive music based on input from finger sensors. The platform combines 11 AI programs to detect emotions and generate music in real time. Across several experiments, people using the device showed reductions in stress and anxiety. Users also stayed more engaged with the therapy sessions. The platform could make it easier for people to access music therapy, which can help reduce stress, anxiety and depression.

, 17, of Andover, Massachusetts, received the聽Craig R. Barrett Award for Innovation鈥痜or $10,000 for developing a new way to sort plastic recyclables using a dissolvable tag. One of the major challenges with plastic recycling is inaccurate sorting of the different plastic types. Colored plastic can also be hard to sort for proper recycling. To improve sorting accuracy, Kevin printed a radio frequency tag on plastic materials. These materials are similar to those used in plastic manufacturing. The tag acts like a wireless barcode, identifying the plastic type for sorting purposes. He made the tag from a conductive material called MXene that can transmit radio frequency signals. The tag is covered by a thin protective coating that dissolves in alkaline water. Experiments showed that both materials quickly break down during the hot washing step already used in recycling plants. Because they wash away, the plastic can be recycled without contamination. Kevin鈥檚 experiments showed the printed tag remained readable for at least six weeks. This practical approach offers a potential way to improve plastic recycling.

, 17, of Rye, New York, received the $10,000 H. Robert Horvitz Prize for Fundamental Research for for studying brain cells using magnets. Nervous system diseases can disrupt calcium signaling in brain cells called astrocytes. Researchers increasingly believe astrocytes play an important role in brain disease, but there are few ways to precisely control them remotely. Inspired by the physics of magnetic levitation, Illaria trialed a way to use magnets to modify signals sent from astrocyte cells. To do this, she first created a material that responds to magnetic fields. In the lab, she added the material to astrocyte cells. When she exposed the cells to magnets, their calcium signaling, which the cells use to communicate, changed. Different magnetic conditions made different patterns. Illaria also studied the biology of the system. She confirmed that a channel in the astrocytes called TRPV4 was responsible for the changes in calcium signaling. Under conditions that mimic a brain injury, she was able to use the system to reduce signs of cellular stress. Her research could help lead to new therapies that regulate brain activity without implanted electrical devices.

, 17, of Orlando, Florida, received the Peggy Scripps Award for Science Communication of $10,000 for creating a carbon dioxide (CO2)-based system that kills honey bee pests. Honey bees are important pollinators that support many global food crops, but up to half of all colonies die off each year. A common pest is the varroa mite. Current treatments for these mites leave chemical residues in honey and beeswax and can harm bees. Aakash鈥檚 earlier work showed that CO2 is an effective way to control the mites while minimizing harm to the bees. For this year鈥檚 project, he tested the long-term safety and real-world performance of his 鈥淢ite Blower鈥� CO2 treatment prototype. His system was as good or better at getting rid of the mites as existing pesticides. It also avoided many of their harmful side effects. In a 10-week field trial of 60 hives, the CO2-treated bees were healthier and made more honey than hives treated with pesticides. Aakash鈥檚 Mite Blower may be a cheaper and safer alternative to treating varroa mite infestations, potentially reducing the loss of hives.

, 18, of Saint Paul, Minnesota, received the $10,000 Mary Sue Coleman Award for Life Science Innovation & Impact聽 for his low-cost system to detect and interrupt seizure-like behavior in a worm model. Some people with epilepsy get brain stimulation to help control seizures. Finding the right stimulation settings often takes months of trial and error. This can be expensive and frustrating for patients.聽To study brain stimulation methods, Evan used gene editing to add an ultrasound-sensitive channel into the brain cells of a worm.聽He then built a computer controller to detect seizure-like activity. When it detected a seizure, the program would trigger an ultrasound to activate the channel and stop the behavior. Using the system, Evan tested different stimulation settings to find which reduced seizures the most. He reduced seizure recurrence by 70.1% and lowered overall seizure activity by聽nearly 30%. His work may lead to faster, lower-cost ways to study brain stimulation in living systems.

, 19, of Lancaster, Pennsylvania, and , 18, of Dubnica nad Vahom, Slovakia, received the Dudley R. Herschbach SIYSS Award.

The winning finalists will receive an all-expense paid trip to attend the Stockholm International Youth Science Seminar during Nobel Week in Stockholm, Sweden.

, 17, of Oviedo, Florida, along with , 17, and , 17, of Mclean, Virginia, received the EU Contest for Young Scientists Award. Their projects will represent Regeneron ISEF at the EU Contest for Young Scientists to be held this September in Kiel, Germany.