京东影业影视传媒 Samantha Maya Milewicz
Samantha studied how the body鈥檚 normal immune reaction to traumatic brain injury can cause secondary damage to the blood brain barrier by overproducing a protein that鈥檚 usually helpful. She observed that by reducing overproduction of MMP-9, the barrier maintained its structure better, which may indicate possible future therapeutic potential.
Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Traumatic Brain Injury Mediated Blood-Brain Barrier Disruption in a Novel Dynamic in vitro Model
Samantha Maya Milewicz, 17, of Armonk, studied how the body鈥檚 immune reaction to traumatic brain injury (TBI) can lead to secondary injury by damaging the protective blood-brain barrier (BBB) for her Regeneron Science Talent Search neuroscience project. One element of this protection is claudin-5, a protein that helps hold the cells that line the brain鈥檚 blood vessels tightly together.聽For her research, Samantha used a model of the BBB that mimicked the conditions of a TBI. She found that following a TBI, the body overproduces a protein called MMP-9; this causes the claudin-5 to degrade and this decreases the barrier鈥檚 protective effect. Using different agents to reduce MMP-9 overproduction, Samantha was able to restore BBB function in the model, providing insight into MMP-9鈥檚 potential as a target for future therapeutic development.
The daughter of Meredith and Steven Milewicz, Samantha presides over four clubs at Byram Hills High School, where she is a member of the principal鈥檚 advisory committee and editor-in-chief of the school paper. She also volunteers as a firefighter, is a nationally certified EMT and a freelance photographer who displays and sells her artistic works at galleries.
Beyond the Project
Samantha presented her study, as first author, at the 18th Annual Academic Surgical Congress in Houston, Texas.
FUN FACTS: On her 16th birthday, Samantha did two things she was finally old enough to do 鈥� apply to the local fire department to become an EMT/firefighter and donate blood. 鈥淚 had to overcome my fear of needles because I was so keen on helping people,鈥� she says.
